Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice
Editor’s summary Relapse of acute myeloid leukemia (AML) is driven by populations of leukemic stem or progenitor cells (LSCs), which are resistant to chemotherapy. Here, Höckendorf et al. found the TNF superfamily member lymphotoxin alpha (Lta) as a repressor of AML. Its genetic deletion promoted AML progression in mouse AML models. Treatment with exogenous, recombinant LTα3 induced cell death […]
XIAP discriminates between type I and type II FAS-induced apoptosis. Nature 2009
XIAP discriminates between type I and type II FAS-inducedapoptosis. Nature 2009
RIPK3 Restricts Myeloid Leukemogenesis
RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death andDifferentiation of Leukemia Initiating Cells. Cancer Cell. 2016