Cycuria’s Scientific Founder Co-Authors A Commemorative Review Article on „Cell Death in Cancer“
Prof Philipp Jost, along with other leading experts in the field, authored an invited commemorative review in Cell by Cell Press — titled “𝘾𝙚𝙡𝙡 𝘿𝙚𝙖𝙩𝙝 𝙞𝙣 𝘾𝙖𝙣𝙘𝙚𝙧”. The review highlights how the expanding landscape of regulated cell death pathways is reshaping our understanding of cancer biology and unlocking new therapeutic opportunities. 🔗 𝗥𝗲𝗮𝗱 𝘁𝗵𝗲 𝗳𝘂𝗹𝗹 […]
Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice
Editor’s summary Relapse of acute myeloid leukemia (AML) is driven by populations of leukemic stem or progenitor cells (LSCs), which are resistant to chemotherapy. Here, Höckendorf et al. found the TNF superfamily member lymphotoxin alpha (Lta) as a repressor of AML. Its genetic deletion promoted AML progression in mouse AML models. Treatment with exogenous, recombinant LTα3 induced cell death […]
XIAP discriminates between type I and type II FAS-induced apoptosis. Nature 2009
XIAP discriminates between type I and type II FAS-inducedapoptosis. Nature 2009
RIPK3 Restricts Myeloid Leukemogenesis
RIPK3 Restricts Myeloid Leukemogenesis by Promoting Cell Death andDifferentiation of Leukemia Initiating Cells. Cancer Cell. 2016